Endocrine Abstracts

Objective: Postoperative nausea and vomiting is common after general anaesthesia and is reported by ~20–25% of all patients. The standard prophylaxis at the authors department is a single treatment of 4 mg of dexamethasone before initiating anesthesia. Dexamethasone is known to suppress ACTH and cortisol levels. The objective was to find out whether the standard PONV-prophylaxis of 4 mg of dexamethasone has an effect on postoperative levels of cortisol in patients undergo...

Objective: Cushing’s disease (CD) may cause atrophy of different regions of the human brain, mostly affecting the hippocampus and the cerebellum. This study evaluates the use of 3-T MRI of newly diagnosed patients with CD to detect atrophic degeneration with voxel-based volumetry.Methods: Subjects with newly diagnosed, untreated CD were included and underwent 3-T MRI. Images were analyzed using a voxelwise statistical test to detect reduction of bra...

Objectives: TSH-producing pituitary adenomas account for 1–2% of all pituitary tumors and there is debate wether transsphenoidal surgery or medical treatment should be recommended as first-line treatment. This study summarizes the authors surgical experience and puts it into context of literature concerning non-surgical treatment of TSHomas.Methods: A retrospective analysis of 12 patients including imaging, laboratory testing, short-term and long-te...

Transsphenoidal surgery is the treatment of choice for acromegaly. Cure is defined by normalization of age-related IGF1 and sufficient suppression of GH in the oral glucose tolerance test (OGTT). We investigated, if early postoperative hormone testing gives reliable information whether complete resection of a tumor was achieved and compared these findings with further follow-up data.So far, 22 patients underwent OGTT within a week after surgery, starting...